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Target
Adenosylhomocysteinase
Ligand
BDBM50006215
Substrate
n/a
Meas. Tech.
ChEBML_196739
IC50
8700±n/a nM
Citation
 Kim, HO; Yoo, SJ; Ahn, HS; Choi, WJ; Moon, HR; Lee, KM; Chun, MW; Jeong, LS Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett 14:2091-3 (2004) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50006215
Synonyms:
(1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)adenine | (1S,2R,5R)-5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | 5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | CHEMBL299961
Type:
Small organic molecule
Emp. Form.:
C10H11N5O2
Mol. Mass.:
233.2266
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O |c:13|
Structure:
Search PDB for entries with ligand similarity: