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Target
Carboxypeptidase B
Ligand
BDBM50144337
Substrate
n/a
Meas. Tech.
ChEBML_45638
IC50
4±n/a nM
Citation
 Nantermet, PG; Barrow, JC; Lindsley, SR; Young, M; Mao, SS; Carroll, S; Bailey, C; Bosserman, M; Colussi, D; McMasters, DR; Vacca, JP; Selnick, HG Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group. Bioorg Med Chem Lett 14:2141-5 (2004) [PubMed]  Article 
Target
Name:
Carboxypeptidase B
Synonyms:
CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI)
Type:
Enzyme
Mol. Mass.:
47367.43
Organism:
Homo sapiens (Human)
Description:
P15086
Residue:
417
Sequence:
MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
  
Inhibitor
Name:
BDBM50144337
Synonyms:
3-(6-Amino-pyridin-3-yl)-2-[1-(4-methyl-pentyl)-1H-imidazol-4-yl]-propionic acid | CHEMBL70177
Type:
Small organic molecule
Emp. Form.:
C17H24N4O2
Mol. Mass.:
316.3981
SMILES:
CC(C)CCCn1cnc(c1)C(Cc1ccc(N)nc1)C(O)=O
Structure:
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