Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase ICK
Ligand
BDBM50577328
Substrate
n/a
Meas. Tech.
ChEMBL_2130031 (CHEMBL4839460)
IC50
>50000±n/a nM
Citation
 Serafim, RAM; Sorrell, FJ; Berger, BT; Collins, RJ; Vasconcelos, SNS; Massirer, KB; Knapp, S; Bennett, J; Fedorov, O; Patel, H; Zuercher, WJ; Elkins, JM Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem 64:13259-13278 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ICK
Synonyms:
CILK1 | CILK1_HUMAN | ICK | Intestinal cell kinase | KIAA0936 | LCK2 | Laryngeal cancer kinase 2 | MAK-related kinase | MRK | hICK
Type:
PROTEIN
Mol. Mass.:
71470.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774570
Residue:
632
Sequence:
MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDWASKYASRR
  
Inhibitor
Name:
BDBM50577328
Synonyms:
CHEMBL4875188
Type:
Small organic molecule
Emp. Form.:
C18H13N3O3
Mol. Mass.:
319.3141
SMILES:
COc1ccccc1C1=C(Nc2cccc(c2)C#N)C(=O)NC1=O |c:9|
Structure:
Search PDB for entries with ligand similarity: