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Target
Cathepsin K
Ligand
BDBM50145457
Substrate
n/a
Meas. Tech.
ChEBML_45555
IC50
14000±n/a nM
Citation
 Barrett, DG; Catalano, JG; Deaton, DN; Long, ST; Miller, LR; Tavares, FX; Wells-Knecht, KJ; Wright, LL; Zhou, HQ Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 14:2543-6 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50145457
Synonyms:
CHEMBL421544 | [(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-carbamic acid 1-isopropyl-2-methyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C19H31N3O5
Mol. Mass.:
381.4665
SMILES:
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)NCc1ccno1
Structure:
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