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Target
Mitogen-activated protein kinase 8
Ligand
BDBM50578352
Substrate
n/a
Meas. Tech.
ChEMBL_2132756 (CHEMBL4842271)
IC50
210±n/a nM
Citation
 Nagy, MA; Hilgraf, R; Mortensen, DS; Elsner, J; Norris, S; Tikhe, J; Yoon, W; Paisner, D; Delgado, M; Erdman, P; Haelewyn, J; Khambatta, G; Xu, L; Romanow, WJ; Condroski, K; Bahmanyar, S; McCarrick, M; Benish, B; Blease, K; LeBrun, L; Moghaddam, MF; Apuy, J; Canan, SS; Bennett, BL; Satoh, Y Discovery of the c-Jun N-Terminal Kinase Inhibitor  J Med Chem 64:18193-18208 (2021) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
Jnk1 | MAP kinase 8 | MAPK 8 | MK08_MOUSE | Mapk8 | Prkm8 | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1
Type:
PROTEIN
Mol. Mass.:
44234.80
Organism:
Mus musculus
Description:
ChEMBL_120521
Residue:
384
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
  
Inhibitor
Name:
BDBM50578352
Synonyms:
CHEMBL4877655
Type:
Small organic molecule
Emp. Form.:
C16H23N5O2
Mol. Mass.:
317.3861
SMILES:
NC(=O)c1cnc(N[C@@H]2CCC[C@H](O)C2)nc1NC12CC(C1)C2 |r|
Structure:
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