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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50579346
Substrate
n/a
Meas. Tech.
ChEMBL_2134929 (CHEMBL4844539)
Ki
110±n/a nM
Citation
 Zajdel, P; Grychowska, K; Mogilski, S; Kurczab, R; Sata?a, G; Bugno, R; Kos, T; Go??biowska, J; Malikowska-Racia, N; Nikiforuk, A; Chaumont-Dubel, S; Bantreil, X; Paw?owski, M; Martinez, J; Subra, G; Lamaty, F; Marin, P; Bojarski, AJ; Popik, P Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT J Med Chem 64:13279-13298 (2021) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
465
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50579346
Synonyms:
CHEMBL4867565
Type:
Small organic molecule
Emp. Form.:
C21H19FN4O2S
Mol. Mass.:
410.465
SMILES:
Fc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
Structure:
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