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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50060686
Substrate
n/a
Meas. Tech.
ChEMBL_2134983 (CHEMBL4844593)
IC50
0.370000±n/a nM
Citation
 Zajdel, P; Grychowska, K; Mogilski, S; Kurczab, R; Sata?a, G; Bugno, R; Kos, T; Go??biowska, J; Malikowska-Racia, N; Nikiforuk, A; Chaumont-Dubel, S; Bantreil, X; Paw?owski, M; Martinez, J; Subra, G; Lamaty, F; Marin, P; Bojarski, AJ; Popik, P Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT J Med Chem 64:13279-13298 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50060686
Synonyms:
4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoline | 4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | CHEMBL327197
Type:
Small organic molecule
Emp. Form.:
C16H18N4
Mol. Mass.:
266.3409
SMILES:
CN1CCN(CC1)c1nc2ccccc2n2cccc12
Structure:
Search PDB for entries with ligand similarity: