Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-17
Ligand
BDBM50146478
Substrate
n/a
Meas. Tech.
ChEBML_106800
IC50
350±n/a nM
Citation
 Kamei, N; Tanaka, T; Kawai, K; Miyawaki, K; Okuyama, A; Murakami, Y; Arakawa, Y; Haino, M; Harada, T; Shimano, M Reverse hydroxamate-based selective TACE inhibitors. Bioorg Med Chem Lett 14:2897-900 (2004) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-17
Synonyms:
MMP-17 | MMP17 | MMP17_HUMAN | MT-MMP 4 | MT4-MMP | MT4MMP | MTMMP4 | Matrix metalloproteinase 17 | Matrix metalloproteinase-17 | Membrane-type matrix metalloproteinase 4 | Membrane-type-4 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
66652.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1433225
Residue:
603
Sequence:
MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL
  
Inhibitor
Name:
BDBM50146478
Synonyms:
CHEMBL98390 | N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylmethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Type:
Small organic molecule
Emp. Form.:
C30H39N3O5S
Mol. Mass.:
553.713
SMILES:
CC(C)CN1CCC(CC(CS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)N(O)C=O)CC1
Structure:
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