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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50579633
Substrate
n/a
Meas. Tech.
ChEMBL_2135962 (CHEMBL4845572)
IC50
11±n/a nM
Citation
 Martínez-González, S; Alvarez, RM; Martín, JI; García, AB; Riesco-Fagundo, C; Varela, C; Rodríguez Hergueta, A; González Cantalapiedra, E; Albarrán, MI; Gómez-Casero, E; Cebriá, A; Aguirre, E; Ajenjo, N; Cebrián, D; Di Geronimo, B; Cunningham, D; O'Neill, M; Dave, HPG; Blanco-Aparicio, C; Pastor, J Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors. ACS Med Chem Lett 12:1794-1801 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50579633
Synonyms:
CHEMBL4854225
Type:
Small organic molecule
Emp. Form.:
C24H16ClN5O4S3
Mol. Mass.:
570.063
SMILES:
COc1ncc-2cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3cc-2sc13
Structure:
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