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Target
Methionine aminopeptidase 2
Ligand
BDBM50147353
Substrate
n/a
Meas. Tech.
ChEBML_105141
IC50
45±n/a nM
Citation
 Sendzik, M; Janc, JW; Cabuslay, R; Honigberg, L; Mackman, RL; Magill, C; Squires, N; Waldeck, N Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth. Bioorg Med Chem Lett 14:3181-4 (2004) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM50147353
Synonyms:
CHEMBL110539 | N-[4-((R)-3-(S)-Amino-5-ethylsulfanyl-2-hydroxy-pentanoylamino)-phenyl]-4-methoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C21H27N3O4S
Mol. Mass.:
417.522
SMILES:
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)c2ccc(OC)cc2)cc1
Structure:
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