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Target
Transcriptional enhancer factor TEF-4
Ligand
BDBM50580859
Substrate
n/a
Meas. Tech.
ChEMBL_2149118 (CHEMBL5033516)
Kd
4600±n/a nM
Citation
 Sturbaut, M; Bailly, F; Coevoet, M; Sileo, P; Pugniere, M; Liberelle, M; Magnez, R; Thuru, X; Chartier-Harlin, MC; Melnyk, P; Gelin, M; Allemand, F; Guichou, JF; Cotelle, P Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur J Med Chem 226:0 (2021) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-4
Synonyms:
TEA domain family member 2 | TEAD-2 | TEAD2 | TEAD2_HUMAN | TEF4 | Transcriptional enhancer factor TEF-4
Type:
PROTEIN
Mol. Mass.:
49241.42
Organism:
Homo sapiens
Description:
ChEMBL_119051
Residue:
447
Sequence:
MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
  
Inhibitor
Name:
BDBM50580859
Synonyms:
CHEMBL5089646
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2N3O3
Mol. Mass.:
432.3
SMILES:
OC(=O)CCCn1cc(C(=O)NCc2ccccc2)c(n1)-c1ccc(Cl)c(Cl)c1
Structure:
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