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Target
Urea transporter 1
Ligand
BDBM50580909
Substrate
n/a
Meas. Tech.
ChEMBL_2149291 (CHEMBL5033689)
IC50
640±n/a nM
Citation
 Wang, S; Xu, Y; Zhao, Y; Zhang, S; Li, M; Li, X; He, J; Zhou, H; Ge, Z; Li, R; Yang, B N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem 226:0 (2021) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM50580909
Synonyms:
CHEMBL5084723
Type:
Small organic molecule
Emp. Form.:
C17H12FN3O6S
Mol. Mass.:
405.357
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Structure:
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