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Target
Urea transporter 1
Ligand
BDBM50580917
Substrate
n/a
Meas. Tech.
ChEMBL_2149292 (CHEMBL5033690)
IC50
480±n/a nM
Citation
 Wang, S; Xu, Y; Zhao, Y; Zhang, S; Li, M; Li, X; He, J; Zhou, H; Ge, Z; Li, R; Yang, B N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem 226:0 (2021) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | Solute carrier family 14 member 1 | UT-B | UT1_MOUSE | Urea transporter B | Urea transporter, erythrocyte
Type:
PROTEIN
Mol. Mass.:
42130.98
Organism:
Mus musculus
Description:
ChEMBL_964780
Residue:
384
Sequence:
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
  
Inhibitor
Name:
BDBM50580917
Synonyms:
CHEMBL5077469
Type:
Small organic molecule
Emp. Form.:
C15H14N2O4
Mol. Mass.:
286.2827
SMILES:
CC(=O)Nc1ccc(NC(=O)c2ccc(o2)C(C)=O)cc1
Structure:
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