Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50581024
Substrate
n/a
Meas. Tech.
ChEMBL_2149614 (CHEMBL5034076)
Kd
1300±n/a nM
Citation
 Huecas, S; Araújo-Bazán, L; Ruiz, FM; Ruiz-Ávila, LB; Martínez, RF; Escobar-Peńa, A; Artola, M; Vázquez-Villa, H; Martín-Fontecha, M; Fernández-Tornero, C; López-Rodríguez, ML; Andreu, JM Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery. J Med Chem 64:5730-5745 (2021) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
40375.29
Organism:
Bacillus subtilis
Description:
ChEMBL_107642
Residue:
382
Sequence:
MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKSQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG
  
Inhibitor
Name:
BDBM50581024
Synonyms:
CHEMBL5092442
Type:
Small organic molecule
Emp. Form.:
C14H10ClF2NO2
Mol. Mass.:
297.685
SMILES:
NC(=O)c1c(F)ccc(OCc2cccc(Cl)c2)c1F
Structure:
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