Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50581031
Substrate
n/a
Meas. Tech.
ChEMBL_2149614 (CHEMBL5034076)
Kd
1900±n/a nM
Citation
 Huecas, S; Araújo-Bazán, L; Ruiz, FM; Ruiz-Ávila, LB; Martínez, RF; Escobar-Peńa, A; Artola, M; Vázquez-Villa, H; Martín-Fontecha, M; Fernández-Tornero, C; López-Rodríguez, ML; Andreu, JM Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery. J Med Chem 64:5730-5745 (2021) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
40375.29
Organism:
Bacillus subtilis
Description:
ChEMBL_107642
Residue:
382
Sequence:
MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKSQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG
  
Inhibitor
Name:
BDBM50581031
Synonyms:
CHEMBL5074266
Type:
Small organic molecule
Emp. Form.:
C18H17F2N5O5
Mol. Mass.:
421.3549
SMILES:
CCC[C@@H](COc1ccc(F)c(C(N)=O)c1F)Nc1ccc([N+]([O-])=O)c2nonc12 |r|
Structure:
Search PDB for entries with ligand similarity: