Reaction Details
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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50581183
Substrate
n/a
Meas. Tech.
ChEMBL_2150072 (CHEMBL5034534)
IC50
0.158489±n/a nM
Citation
Armani, E; Rizzi, A; Capaldi, C; De Fanti, R; Delcanale, M; Villetti, G; Marchini, G; Pisano, AR; Pitozzi, V; Pittelli, MG; Trevisani, M; Salvadori, M; Cenacchi, V; Puccini, P; Amadei, F; Pappani, A; Civelli, M; Patacchini, R; Baker-Glenn, CAG; Van de Poël, H; Blackaby, WP; Nash, K; Amari, G Discovery of M J Med Chem 64:9100-9119 (2021) [PubMed] Article More Info.:
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
Inhibitor
Name:
BDBM50581183
Synonyms:
CHEMBL5087564
Type:
Small organic molecule
Emp. Form.:
C37H37Cl2N3O7
Mol. Mass.:
706.612
SMILES:
COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c1 |r,wU:10.22,wD:34.35,(2.97,-32.16,;4.31,-32.93,;5.64,-32.16,;6.98,-32.94,;8.31,-32.16,;8.31,-30.61,;6.97,-29.85,;5.64,-30.62,;4.31,-29.85,;4.31,-28.31,;9.64,-29.84,;10.98,-30.6,;12.31,-29.83,;12.29,-28.3,;10.95,-27.54,;13.62,-27.52,;14.96,-28.28,;16.29,-27.51,;14.97,-29.83,;13.64,-30.6,;13.64,-32.14,;9.63,-28.3,;8.3,-27.53,;6.97,-28.31,;8.29,-25.99,;6.96,-25.24,;6.95,-23.7,;8.28,-22.92,;9.62,-23.68,;10.95,-22.91,;10.95,-21.37,;12.28,-20.59,;12.27,-19.06,;13.61,-21.36,;14.94,-20.59,;16.28,-21.36,;17.61,-20.59,;17.61,-19.05,;16.27,-18.28,;14.93,-19.05,;15.79,-20.46,;16.82,-19.25,;9.61,-20.6,;9.61,-19.06,;8.28,-18.3,;6.95,-19.07,;6.96,-20.62,;8.29,-21.38,;9.62,-25.22,)|
Structure:
