Reaction Details Report a problem with these data
Target
Plasminogen activator inhibitor 1
Ligand
BDBM50149275
Substrate
n/a
Meas. Tech.
ChEMBL_155742 (CHEMBL760892)
Kd
480±n/a nM
Citation
 Elokdah, H; Abou-Gharbia, M; Hennan, JK; McFarlane, G; Mugford, CP; Krishnamurthy, G; Crandall, DL Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem 47:3491-4 (2004) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1_RAT | Pai1 | Planh1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor-1 | Serpine1
Type:
PROTEIN
Mol. Mass.:
45009.76
Organism:
Rattus norvegicus
Description:
ChEMBL_155741
Residue:
402
Sequence:
MQMSSALTCLTLGLVLVFGKGFASPLPESHTAQQATNFGVKVFQHVVQASKDRNVVFSPYGVSSVLAMLQLTTAGKTRQQIQDAMGFNISERGTAPALRKLSKELMGSWNKNEISTADAIFVQRDLELVQGFMPHFFKLFRTTVKQVDFSEVERARFIINDWVERHTKGMISDLLAKGAVNELTRLVLVNALYFNGQWKTPFLEASTHQRLFHKSDGSTISVPMMAQNNKFNYTEFTTPDGHEYDILELPYHGETLSMFIAAPFEKDVPLSAITNILDAELIRQWKSNMTRLPRLLILPKFSLETEVDLRGPLEKLGMTDIFSSTQADFTSLSDQEQLSVAQALQKVKIEVNESGTVASSSTAILVSARMAPTEMVLDRSFLFVVRHNPTETILFMGQLMEP
  
Inhibitor
Name:
BDBM50149275
Synonyms:
2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid | CHEMBL325441 | [1-Benzyl-5-(4-trifluoromethoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acid | [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid
Type:
Small organic molecule
Emp. Form.:
C24H16F3NO4
Mol. Mass.:
439.3833
SMILES:
OC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1
Structure:
Search PDB for entries with ligand similarity: