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Target
Neuropeptide FF receptor 1
Ligand
BDBM50581390
Substrate
n/a
Meas. Tech.
ChEMBL_2150933 (CHEMBL5035395)
EC50
90±n/a nM
Citation
 Zhang, M; Xu, B; Li, N; Zhang, R; Zhang, Q; Shi, X; Xu, K; Xiao, J; Chen, D; Niu, J; Shi, Y; Fang, Q Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. J Med Chem 64:13394-13409 (2021) [PubMed]  Article 
Target
Name:
Neuropeptide FF receptor 1
Synonyms:
G-protein coupled receptor 147 | GPR147 | NPFF1 | NPFF1_HUMAN | NPFFR1 | RFamide-related peptide receptor OT7T022
Type:
PROTEIN
Mol. Mass.:
47840.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1474637
Residue:
430
Sequence:
MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
  
Inhibitor
Name:
BDBM50581390
Synonyms:
CHEMBL5082892
Type:
Small organic molecule
Emp. Form.:
C53H71N15O12
Mol. Mass.:
1110.2241
SMILES:
CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Structure:
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