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Target
Mixed lineage kinase domain-like protein
Ligand
BDBM50581528
Substrate
n/a
Meas. Tech.
ChEMBL_2151280 (CHEMBL5035742)
Kd
1807000±n/a nM
Citation
 Rübbelke, M; Hamilton, J; Binder, F; Bauer, M; King, J; Nar, H; Zeeb, M Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem 64:15629-15638 (2021) [PubMed]  Article 
Target
Name:
Mixed lineage kinase domain-like protein
Synonyms:
MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL
Type:
PROTEIN
Mol. Mass.:
54493.57
Organism:
Homo sapiens
Description:
ChEMBL_104428
Residue:
471
Sequence:
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
  
Inhibitor
Name:
BDBM50581528
Synonyms:
CHEMBL5070147
Type:
Small organic molecule
Emp. Form.:
C17H18N2O
Mol. Mass.:
266.3376
SMILES:
CC(C)c1ccc(cc1)[C@H](O)c1nc2ccccc2[nH]1 |r|
Structure:
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