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Target
Mixed lineage kinase domain-like protein
Ligand
BDBM50581534
Substrate
n/a
Meas. Tech.
ChEMBL_2151280 (CHEMBL5035742)
Kd
5528000±n/a nM
Citation
 Rübbelke, M; Hamilton, J; Binder, F; Bauer, M; King, J; Nar, H; Zeeb, M Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem 64:15629-15638 (2021) [PubMed]  Article 
Target
Name:
Mixed lineage kinase domain-like protein
Synonyms:
MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL
Type:
PROTEIN
Mol. Mass.:
54493.57
Organism:
Homo sapiens
Description:
ChEMBL_104428
Residue:
471
Sequence:
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
  
Inhibitor
Name:
BDBM50581534
Synonyms:
CHEMBL1738948
Type:
Small organic molecule
Emp. Form.:
C21H40O11
Mol. Mass.:
468.5357
SMILES:
CCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Structure:
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