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Target
Mixed lineage kinase domain-like protein
Ligand
BDBM50581530
Substrate
n/a
Meas. Tech.
ChEMBL_2151282 (CHEMBL5035744)
Kd
215000±n/a nM
Citation
 Rübbelke, M; Hamilton, J; Binder, F; Bauer, M; King, J; Nar, H; Zeeb, M Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem 64:15629-15638 (2021) [PubMed]  Article 
Target
Name:
Mixed lineage kinase domain-like protein
Synonyms:
MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL
Type:
PROTEIN
Mol. Mass.:
54493.57
Organism:
Homo sapiens
Description:
ChEMBL_104428
Residue:
471
Sequence:
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
  
Inhibitor
Name:
BDBM50581530
Synonyms:
CHEMBL5086911
Type:
Small organic molecule
Emp. Form.:
C19H20N2O3
Mol. Mass.:
324.3737
SMILES:
CO[C@H](c1nc2ccc(cc2[nH]1)C(O)=O)c1ccc(cc1)C(C)C |r|
Structure:
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