Reaction Details
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Solute carrier organic anion transporter family member 1B1
Ligand
BDBM50581550
Substrate
n/a
Meas. Tech.
ChEMBL_2151404 (CHEMBL5035866)
IC50
170±n/a nM
Citation
Cheng, PTW; Kaltenbach, RF; Zhang, H; Shi, J; Tao, S; Li, J; Kennedy, LJ; Walker, SJ; Shi, Y; Wang, Y; Dhanusu, S; Reddigunta, R; Kumaravel, S; Jusuf, S; Smith, D; Krishnananthan, S; Li, J; Wang, T; Heiry, R; Sum, CS; Kalinowski, SS; Hung, CP; Chu, CH; Azzara, AV; Ziegler, M; Burns, L; Zinker, BA; Boehm, S; Taylor, J; Sapuppo, J; Mosure, K; Everlof, G; Guarino, V; Zhang, L; Yang, Y; Ruan, Q; Xu, C; Apedo, A; Traeger, SC; Cvijic, ME; Lentz, KA; Tirucherai, G; Sivaraman, L; Robl, J; Ellsworth, BA; Rosen, G; Gordon, DA; Soars, MG; Gill, M; Murphy, BJ Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA J Med Chem 64:15549-15581 (2021) [PubMed] Article More Info.:
Target
Name:
Solute carrier organic anion transporter family member 1B1
Synonyms:
LST1 | OATP1B1 | OATP2 | OATPC | SLC21A6 | SLCO1B1 | SO1B1_HUMAN | Solute carrier organic anion transporter family member 1B1 | Solute carrier organic anion transporter family member 1B1 (OATP1B1) | Thromboxane B2
Type:
Protein
Mol. Mass.:
76468.06
Organism:
Homo sapiens (Human)
Description:
Q9Y6L6
Residue:
691
Sequence:
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
Inhibitor
Name:
BDBM50581550
Synonyms:
AP-3152 FREE ACID | BMS-986020 | Bms-986020
Type:
Small organic molecule
Emp. Form.:
C29H26N2O5
Mol. Mass.:
482.5271
SMILES:
C[C@@H](OC(=O)Nc1c(C)noc1-c1ccc(cc1)-c1ccc(cc1)C1(CC1)C(O)=O)c1ccccc1
Structure:
