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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM50099062
Substrate
n/a
Meas. Tech.
ChEMBL_2151709 (CHEMBL5036171)
Kd
113±n/a nM
Citation
 Klein, VG; Bond, AG; Craigon, C; Lokey, RS; Ciulli, A Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem 64:18082-18101 (2021) [PubMed]  Article 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM50099062
Synonyms:
CHEMBL3344081 | US10730870, Example 3 | US11512083, Example 3
Type:
Small organic molecule
Emp. Form.:
C24H32N4O4S
Mol. Mass.:
472.6
SMILES:
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r|
Structure:
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