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Target
Galectin-3
Ligand
BDBM50581762
Substrate
n/a
Meas. Tech.
ChEMBL_2152216 (CHEMBL5036763)
IC50
10.0±n/a nM
Citation
Xu, L; Hartz, RA; Beno, BR; Ghosh, K; Shukla, JK; Kumar, A; Patel, D; Kalidindi, N; Lemos, N; Gautam, SS; Kumar, A; Ellsworth, BA; Shah, D; Sale, H; Cheng, D; Regueiro-Ren, A Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors. J Med Chem 64:6634-6655 (2021) [PubMed] Article
More Info.:
Target
Name:
Galectin-3
Synonyms:
LEG3_HUMAN | LGALS3 | MAC2
Type:
Enzyme
Mol. Mass.:
26156.54
Organism:
Homo sapiens (Human)
Description:
P17931
Residue:
250
Sequence:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
Inhibitor
Name:
BDBM50581762
Synonyms:
GB-0139 | GB0139 | OLITIGALTIN | Olitigaltin | TD-139 | TD139 | Td 139 | Td-139 | Td139
Type:
Small organic molecule
Emp. Form.:
C28H30F2N6O8S
Mol. Mass.:
648.635
SMILES:
OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@@H]([C@H]2O)n2cc(nn2)-c2cccc(F)c2)[C@H](O)[C@H]([C@H]1O)n1cc(nn1)-c1cccc(F)c1 |r|