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Target
G-protein coupled receptor 6
Ligand
BDBM50582422
Substrate
n/a
Meas. Tech.
ChEMBL_2154533 (CHEMBL5039193)
EC50
4100±n/a nM
Citation
 Sun, H; Monenschein, H; Schiffer, HH; Reichard, HA; Kikuchi, S; Hopkins, M; Macklin, TK; Hitchcock, S; Adams, M; Green, J; Brown, J; Murphy, ST; Kaushal, N; Collia, DR; Moore, S; Ray, WJ; English, NM; Carlton, MBL; Brice, NL First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate. J Med Chem 64:9875-9890 (2021) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM50582422
Synonyms:
CHEMBL3719410
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2N5O
Mol. Mass.:
458.384
SMILES:
COc1ccc2nc(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)c(NC3CC3)nc2c1
Structure:
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