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Target
Cyclic GMP-AMP synthase
Ligand
BDBM50582657
Substrate
n/a
Meas. Tech.
ChEMBL_2155378 (CHEMBL5040038)
IC50
14±n/a nM
Citation
 Tan, J; Wu, B; Chen, T; Fan, C; Zhao, J; Xiong, C; Feng, C; Xiao, R; Ding, C; Tang, W; Zhang, A Synthesis and Pharmacological Evaluation of Tetrahydro-?-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J Med Chem 64:7667-7690 (2021) [PubMed]  Article 
Target
Name:
Cyclic GMP-AMP synthase
Synonyms:
2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS
Type:
PROTEIN
Mol. Mass.:
58845.55
Organism:
Homo sapiens
Description:
ChEMBL_117333
Residue:
522
Sequence:
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
  
Inhibitor
Name:
BDBM50582657
Synonyms:
CHEMBL5082056
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N4O2
Mol. Mass.:
379.241
SMILES:
Cn1ccc(n1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO
Structure:
Search PDB for entries with ligand similarity: