Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 2
Ligand
BDBM50151792
Substrate
n/a
Meas. Tech.
ChEMBL_305345 (CHEMBL832725)
IC50
29750±n/a nM
Citation
 Xu, J; Ok, HO; Gonzalez, EJ; Colwell, LF; Habulihaz, B; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Wu, JK; Thornberry, NA; Weber, AE; Parmee, ER Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 14:4759-62 (2004) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
  
Inhibitor
Name:
BDBM50151792
Synonyms:
3-((R)-2-Amino-4-oxo-4-thiazolidin-3-yl-butyl)-benzonitrile | CHEMBL405786
Type:
Small organic molecule
Emp. Form.:
C14H17N3OS
Mol. Mass.:
275.369
SMILES:
N[C@@H](CC(=O)N1CCSC1)Cc1cccc(c1)C#N
Structure:
Search PDB for entries with ligand similarity: