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Target
Lysosomal alpha-glucosidase
Ligand
BDBM18354
Substrate
n/a
Meas. Tech.
ChEMBL_2157198 (CHEMBL5041858)
Ki
360±n/a nM
Citation
 Kato, A; Nakagome, I; Kanekiyo, U; Lu, TT; Li, YX; Yoshimura, K; Kishida, M; Shinzawa, K; Yoshida, T; Tanaka, N; Jia, YM; Nash, RJ; Fleet, GWJ; Yu, CY 5- J Med Chem 65:2329-2341 (2022) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
105312.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506060
Residue:
952
Sequence:
MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGASRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGAQMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPVEALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
  
Inhibitor
Name:
BDBM18354
Synonyms:
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine-3,4,5-triol | N-Propyl-DNJ
Type:
Small organic molecule
Emp. Form.:
C9H19NO4
Mol. Mass.:
205.2515
SMILES:
CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure:
Search PDB for entries with ligand similarity: