Reaction Details
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Mas-related G-protein coupled receptor member X1
Ligand
BDBM50583469
Substrate
n/a
Meas. Tech.
ChEMBL_2157377 (CHEMBL5042037)
EC50
300±n/a nM
Citation
Berhane, I; Hin, N; Thomas, AG; Huang, Q; Zhang, C; Veeravalli, V; Wu, Y; Ng, J; Alt, J; Rojas, C; Hihara, H; Aoki, M; Yoshizawa, K; Nishioka, T; Suzuki, S; He, SQ; Peng, Q; Guan, Y; Dong, X; Raja, SN; Slusher, BS; Rais, R; Tsukamoto, T Thieno[2,3- J Med Chem 65:3218-3228 (2022) [PubMed] Article More Info.:
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4
Type:
PROTEIN
Mol. Mass.:
36253.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_516621
Residue:
322
Sequence:
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
Inhibitor
Name:
BDBM50583469
Synonyms:
CHEMBL5076018
Type:
Small organic molecule
Emp. Form.:
C22H18F2N2OS
Mol. Mass.:
396.453
SMILES:
CC(C)(C)c1sc2ncnc(Oc3ccccc3F)c2c1-c1ccc(F)cc1
Structure:
