Target
Serine/threonine-protein kinase 3
Ligand
BDBM50059345
Substrate
n/a
Meas. Tech.
ChEMBL_2158673 (CHEMBL5043423)
Ki
89±n/a nM
Citation
 Bata, NChaikuad, ABakas, NALimpert, ASLambert, LJSheffler, DJBerger, LMLiu, GYuan, CWang, LPeng, YDong, JCeleridad, MLayng, FKnapp, SCosford, NDP Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J Med Chem 65:1352-1369 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 3
Synonyms:
KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
56284.87
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
491
Sequence:
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
  
Inhibitor
Name:
BDBM50059345
Synonyms:
CHEMBL3393355 | US9156845, 83
Type:
Small organic molecule
Emp. Form.:
C16H15ClN4O
Mol. Mass.:
314.77
SMILES:
Clc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Structure:
Search PDB for entries with ligand similarity: