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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50584106
Substrate
n/a
Meas. Tech.
ChEMBL_2158995 (CHEMBL5043745)
IC50
<1.000000±n/a nM
Citation
 Halland, N; Schmidt, F; Weiss, T; Li, Z; Czech, J; Saas, J; Ding-Pfennigdorff, D; Dreyer, MK; Strübing, C; Nazare, M Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem 65:1567-1584 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50584106
Synonyms:
CHEMBL5080922
Type:
Small organic molecule
Emp. Form.:
C22H19Cl2N5O4S
Mol. Mass.:
520.388
SMILES:
CN(CCO)C(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1
Structure:
Search PDB for entries with ligand similarity: