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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50584667
Substrate
n/a
Meas. Tech.
ChEMBL_2160305 (CHEMBL5045055)
Ki
790±n/a nM
Citation
 Golovanov, A; Zhuravlev, A; Cruz, A; Aksenov, V; Shafiullina, R; Kakularam, KR; Lluch, JM; Kuhn, H; González-Lafont, Ŕ; Ivanov, I -Substituted 5-(1 J Med Chem 65:1979-1995 (2022) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase
Type:
Enzyme
Mol. Mass.:
75309.71
Organism:
Oryctolagus cuniculus (rabbit)
Description:
15-LO enzyme was purified from phenylhydrazine treated rabbits.
Residue:
663
Sequence:
MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLAWGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRDQPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI
  
Inhibitor
Name:
BDBM50584667
Synonyms:
CHEMBL5080282
Type:
Small organic molecule
Emp. Form.:
C23H29N3O4S
Mol. Mass.:
443.559
SMILES:
CCCCCCCCOC(=O)NS(=O)(=O)Nc1cccc(c1)-c1cc2ccccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: