Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50584744
Substrate
n/a
Meas. Tech.
ChEMBL_2160522 (CHEMBL5045272)
IC50
15±n/a nM
Citation
 He, Y; Schild, M; Grether, U; Benz, J; Leibrock, L; Heer, D; Topp, A; Collin, L; Kuhn, B; Wittwer, M; Keller, C; Gobbi, LC; Schibli, R; Mu, L Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. J Med Chem 65:2191-2207 (2022) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mouse
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50584744
Synonyms:
CHEMBL5084120
Type:
Small organic molecule
Emp. Form.:
C26H27N3O4
Mol. Mass.:
445.5103
SMILES:
COc1cccc(c1)-c1cccc(c1)N1CC(CC1=O)N1CCN(CC1)C(=O)c1ccco1
Structure:
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