Target
Stimulator of interferon genes protein
Ligand
BDBM50584863
Substrate
n/a
Meas. Tech.
ChEMBL_2160789 (CHEMBL5045539)
EC50
32000±n/a nM
Citation
 Cherney, ECZhang, LLo, JHuynh, TWei, DAhuja, VQuesnelle, CSchieven, GLFutran, ALocke, GALin, ZMonereau, LChaudhry, CBlum, JLi, SFereshteh, MLi-Wang, BGangwar, SPan, CChong, CZhu, XPosy, SLSack, JSZhang, PRuzanov, MHarner, MAkhtar, FSchroeder, GMVite, GFink, B Discovery of Non-Nucleotide Small-Molecule STING Agonists  J Med Chem 65:3518-3538 (2022) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50584863
Synonyms:
CHEMBL5077683
Type:
Small organic molecule
Emp. Form.:
C18H13ClN4O4
Mol. Mass.:
384.773
SMILES:
Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1
Structure:
Search PDB for entries with ligand similarity: