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Target
Estrogen receptor beta
Ligand
BDBM50154088
Substrate
n/a
Meas. Tech.
ChEMBL_306448 (CHEMBL829092)
IC50
1.7±n/a nM
Citation
 Malamas, MS; Manas, ES; McDevitt, RE; Gunawan, I; Xu, ZB; Collini, MD; Miller, CP; Dinh, T; Henderson, RA; Keith, JC; Harris, HA Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem 47:5021-40 (2004) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2_MOUSE | Esr2 | Estrb | Estrb | Estrogen receptor | Estrogen receptor beta | Nr3a2 | Nuclear receptor subfamily 3 group A member 2
Type:
PROTEIN
Mol. Mass.:
59091.81
Organism:
Mus musculus
Description:
ChEMBL_306448
Residue:
530
Sequence:
MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
  
Inhibitor
Name:
BDBM50154088
Synonyms:
7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol | 7-bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | CHEMBL188528
Type:
Small organic molecule
Emp. Form.:
C13H8BrNO3
Mol. Mass.:
306.112
SMILES:
Oc1ccc(cc1)-c1nc2cc(O)cc(Br)c2o1
Structure:
Search PDB for entries with ligand similarity: