Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase ULK3
Ligand
BDBM50585187
Substrate
n/a
Meas. Tech.
ChEMBL_2161745 (CHEMBL5046606)
IC50
343±n/a nM
Citation
 Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem 65:1313-1328 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ULK3
Synonyms:
ULK3 | ULK3_HUMAN
Type:
PROTEIN
Mol. Mass.:
53449.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774298
Residue:
472
Sequence:
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
  
Inhibitor
Name:
BDBM50585187
Synonyms:
CHEMBL5079601
Type:
Small organic molecule
Emp. Form.:
C21H28F3N7O
Mol. Mass.:
451.4885
SMILES:
Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCCCNC(=O)C2CCC2)n1
Structure:
Search PDB for entries with ligand similarity: