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Target
DNA polymerase I
Ligand
BDBM50154442
Substrate
n/a
Meas. Tech.
ChEMBL_305663 (CHEMBL828714)
IC50
>100000±n/a nM
Citation
 Summa, V; Petrocchi, A; Matassa, VG; Taliani, M; Laufer, R; De Francesco, R; Altamura, S; Pace, P HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis. J Med Chem 47:5336-9 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase I
Synonyms:
DPO1_ECOLI | polA | resA
Type:
PROTEIN
Mol. Mass.:
103100.24
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_305663
Residue:
928
Sequence:
MVQIPQNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLIMQYKPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLLAVSGVEADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPNITLINTMTNTILGPEEVVNKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAEELLGLFKKYEFKRWTADVEAGKWLQAKGAKPAAKPQETSVADEAPEVTATVISYDNYVTILDEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENWDQAH
  
Inhibitor
Name:
BDBM50154442
Synonyms:
2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid | CHEMBL188448
Type:
Small organic molecule
Emp. Form.:
C11H7ClN2O4
Mol. Mass.:
266.637
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Structure:
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