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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50154717
Substrate
n/a
Meas. Tech.
ChEMBL_302663 (CHEMBL839951)
Ki
390±n/a nM
Citation
 Vermeulen, ES; van Smeden, M; Schmidt, AW; Sprouse, JS; Wikström, HV; Grol, CJ Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides. J Med Chem 47:5451-66 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50154717
Synonyms:
CHEMBL360382 | Naphthalene-1-sulfonic acid [3-(6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propyl]-amide
Type:
Small organic molecule
Emp. Form.:
C23H26N2O3S
Mol. Mass.:
410.529
SMILES:
COc1ccc2CN(CCCNS(=O)(=O)c3cccc4ccccc34)CCc2c1
Structure:
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