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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50586451
Substrate
n/a
Meas. Tech.
ChEMBL_2168722 (CHEMBL5053781)
EC50
37±n/a nM
Citation
 Qiu, R; Yu, M; Gong, J; Tian, J; Huang, Y; Wang, Y; Xie, Q Discovery of tert-amine-based ROR?t agonists. Eur J Med Chem 224:0 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor
Type:
PROTEIN
Mol. Mass.:
58133.31
Organism:
Mus musculus
Description:
ChEMBL_103664
Residue:
516
Sequence:
MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
  
Inhibitor
Name:
BDBM50586451
Synonyms:
CHEMBL5086647
Type:
Small organic molecule
Emp. Form.:
C26H35ClN2O3S
Mol. Mass.:
491.086
SMILES:
CCCN(CC1CCCCC1)Cc1ccc(NC(=O)Cc2ccc(cc2)S(C)(=O)=O)cc1Cl
Structure:
Search PDB for entries with ligand similarity: