Reaction Details
Report a problem with these data
Report a problem with these dataTarget
5-hydroxytryptamine receptor 2B
Ligand
BDBM50133231
Substrate
n/a
Meas. Tech.
ChEMBL_2168955 (CHEMBL5054014)
Ki
2.2±n/a nM
Citation
León, F; Obeng, S; Mottinelli, M; Chen, Y; King, TI; Berthold, EC; Kamble, SH; Restrepo, LF; Patel, A; Gamez-Jimenez, LR; Lopera-Londoño, C; Hiranita, T; Sharma, A; Hampson, AJ; Canal, CE; McMahon, LR; McCurdy, CR Activity of J Med Chem 64:13510-13523 (2021) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
Inhibitor
Name:
BDBM50133231
Synonyms:
(R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | (R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine | CHEMBL134519
Type:
Small organic molecule
Emp. Form.:
C11H16INO2
Mol. Mass.:
321.1547
SMILES:
COc1cc(C[C@@H](C)N)c(OC)cc1I
Structure:
