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Target
Phenylalanine-4-hydroxylase
Ligand
BDBM50156156
Substrate
n/a
Meas. Tech.
ChEMBL_305560 (CHEMBL828579)
IC50
1000±n/a nM
Citation
 Teigen, K; Dao, KK; McKinney, JA; Gorren, AC; Mayer, B; Frøystein, NA; Haavik, J; Martínez, A Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. J Med Chem 47:5962-71 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine-4-hydroxylase
Synonyms:
PAH | PH4H_HUMAN | Phe-4-monooxygenase
Type:
PROTEIN
Mol. Mass.:
51861.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305560
Residue:
452
Sequence:
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK
  
Inhibitor
Name:
BDBM50156156
Synonyms:
2-Amino-7-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one | CHEMBL187878
Type:
Small organic molecule
Emp. Form.:
C9H15N5O3
Mol. Mass.:
241.2471
SMILES:
CC(O)C(O)C1CNc2c(N1)nc(N)[nH]c2=O
Structure:
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