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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50586741
Substrate
n/a
Meas. Tech.
ChEMBL_2169551 (CHEMBL5054610)
EC50
2.0±n/a nM
Citation
 Lu, B; Liu, D; Gui, B; Gou, J; Dong, H; Hu, Q; Feng, J; Mao, Y; Shen, X; Wang, S; Zhang, C; Shen, R; Yan, Y; Chen, L; Wang, H; Li, D; Zhang, J; Zhang, M; Zhang, R; Bai, C; He, F; Tao, W; Liu, S Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable ROR? Agonists with Antitumor Activity. J Med Chem 64:14983-14996 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50586741
Synonyms:
CHEMBL5083464
Type:
Small organic molecule
Emp. Form.:
C28H25ClF4N2O3S
Mol. Mass.:
581.021
SMILES:
CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3n(CCF)c(Cc4ccc(Cl)cc4C(F)(F)F)cc3c2)cc1
Structure:
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