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Target
Disintegrin and metalloproteinase domain-containing protein 12
Ligand
BDBM50156475
Substrate
n/a
Meas. Tech.
ChEMBL_306185 (CHEMBL830979)
IC50
24.8±n/a nM
Citation
 Oh, M; Im, I; Lee, YJ; Kim, YH; Yoon, JH; Park, HG; Higashiyama, S; Kim, YC; Park, WJ Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg Med Chem Lett 14:6071-4 (2004) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 12
Synonyms:
ADA12_HUMAN | ADAM12 | MLTN
Type:
PROTEIN
Mol. Mass.:
99581.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306185
Residue:
909
Sequence:
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
  
Inhibitor
Name:
BDBM50156475
Synonyms:
2-[2-[(5-Bromo-furan-2-carbonyl)-amino]-3-(4-bromo-phenyl)-acryloylamino]-propionic acid | CHEMBL361087
Type:
Small organic molecule
Emp. Form.:
C17H14Br2N2O5
Mol. Mass.:
486.111
SMILES:
CC(NC(=O)C(\NC(=O)c1ccc(Br)o1)=C/c1ccc(Br)cc1)C(O)=O
Structure:
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