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Target
Cathepsin D
Ligand
BDBM134293
Substrate
n/a
Meas. Tech.
ChEMBL_2170797 (CHEMBL5055931)
IC50
>10000±n/a nM
Citation
Rueeger, H; Lueoend, R; Machauer, R; Veenstra, SJ; Holzer, P; Hurth, K; Voegtle, M; Frederiksen, M; Rondeau, JM; Tintelnot-Blomley, M; Jacobson, LH; Staufenbiel, M; Laue, G; Neumann, U Synthesis of the Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor NB-360. J Med Chem 64:4677-4696 (2021) [PubMed] Article
More Info.:
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL