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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50587577
Substrate
n/a
Meas. Tech.
ChEMBL_2172849 (CHEMBL5057983)
IC50
62±n/a nM
Citation
 He, X; He, G; Chu, Z; Wu, H; Wang, J; Ge, Y; Shen, H; Zhang, S; Shan, J; Peng, K; Wei, Z; Zou, Y; Xu, Y; Zhu, Q Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem 64:17950-17968 (2021) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50587577
Synonyms:
CHEMBL5091415
Type:
Small organic molecule
Emp. Form.:
C19H22BrFN8O3
Mol. Mass.:
509.332
SMILES:
O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCn1cc(nn1)C1(O)CCCCC1
Structure:
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