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Target
17-beta-hydroxysteroid dehydrogenase type 1
Ligand
BDBM50587607
Substrate
n/a
Meas. Tech.
ChEMBL_2173334 (CHEMBL5058468)
IC50
2.7±n/a nM
Citation
 Gargano, EM; Mohamed, A; Abdelsamie, AS; Mangiatordi, GF; Drzewiecka, H; Jagodzi?ski, PP; Mazzini, A; van Koppen, CJ; Laschke, MW; Nicolotti, O; Carotti, A; Marchais-Oberwinkler, S; Hartmann, RW; Frotscher, M 17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer. ACS Med Chem Lett 12:1920-1924 (2021) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 1
Synonyms:
17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1
Type:
Enzyme
Mol. Mass.:
34945.13
Organism:
Homo sapiens (Human)
Description:
P14061
Residue:
328
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
  
Inhibitor
Name:
BDBM50587607
Synonyms:
CHEMBL5089787
Type:
Small organic molecule
Emp. Form.:
C19H16ClNO3
Mol. Mass.:
341.788
SMILES:
CN(C(=O)c1ccc(o1)-c1ccc(O)c(Cl)c1)c1ccccc1C
Structure:
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