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Target
NUAK family SNF1-like kinase 1
Ligand
BDBM50587674
Substrate
n/a
Meas. Tech.
ChEMBL_2184482 (CHEMBL5096564)
IC50
33±n/a nM
Citation
 Faisal, M; Kim, JH; Yoo, KH; Roh, EJ; Hong, SS; Lee, SH Development and Therapeutic Potential of NUAKs Inhibitors. J Med Chem 64:2-25 (2021) [PubMed] 
Target
Name:
NUAK family SNF1-like kinase 1
Synonyms:
ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1
Type:
PROTEIN
Mol. Mass.:
74326.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451343
Residue:
661
Sequence:
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
  
Inhibitor
Name:
BDBM50587674
Synonyms:
CHEMBL1643963
Type:
Small organic molecule
Emp. Form.:
C25H26N8O2
Mol. Mass.:
470.5263
SMILES:
CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3nc[nH]c3n2)cc1
Structure:
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