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Target
NUAK family SNF1-like kinase 1
Ligand
BDBM50111572
Substrate
n/a
Meas. Tech.
ChEMBL_2184485 (CHEMBL5096567)
IC50
230±n/a nM
Citation
 Faisal, M; Kim, JH; Yoo, KH; Roh, EJ; Hong, SS; Lee, SH Development and Therapeutic Potential of NUAKs Inhibitors. J Med Chem 64:2-25 (2021) [PubMed] 
Target
Name:
NUAK family SNF1-like kinase 1
Synonyms:
ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1
Type:
PROTEIN
Mol. Mass.:
74326.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451343
Residue:
661
Sequence:
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
  
Inhibitor
Name:
BDBM50111572
Synonyms:
CHEMBL3605057
Type:
Small organic molecule
Emp. Form.:
C26H36N6O2
Mol. Mass.:
464.603
SMILES:
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
Structure:
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