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Target
Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM50511105
Substrate
n/a
Meas. Tech.
ChEMBL_2184547 (CHEMBL5096629)
EC50
3800±n/a nM
Citation
 Sampson, PB Phytocannabinoid Pharmacology: Medicinal Properties of  J Nat Prod 84:142-160 (2021) [PubMed] 
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
  
Inhibitor
Name:
BDBM50511105
Synonyms:
GWP-42004 | Gwp42004 | O-4394 | THCV | Tetrahydrocannabivarin
Type:
Small organic molecule
Emp. Form.:
C19H26O2
Mol. Mass.:
286.4085
SMILES:
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)Oc1cc(CCC)cc(O)c21 |r,t:2|
Structure:
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