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Target
Reduced folate transporter
Ligand
BDBM50158569
Substrate
n/a
Meas. Tech.
ChEMBL_430664 (CHEMBL919632)
Ki
280±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Wright, JE Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem 47:6958-63 (2004) [PubMed]  Article 
Target
Name:
Reduced folate transporter
Synonyms:
FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1
Type:
PROTEIN
Mol. Mass.:
64885.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469594
Residue:
591
Sequence:
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
  
Inhibitor
Name:
BDBM50158569
Synonyms:
2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-dihydro-1-oxo--2(1H)-isoindolyl glutaric acid | CHEMBL390990
Type:
Small organic molecule
Emp. Form.:
C20H20N8O5
Mol. Mass.:
452.4234
SMILES:
Nc1nc(N)c2nc(CNc3ccc4C(=O)N(Cc4c3)[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |r|
Structure:
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